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Peptide pools are powerful tools in immune research: They allow you to monitor antigens and evaluate T mobile responses successfully and price-correctly. Peptide pools typically depict an entire protein by mapping its Principal peptides shop amino acid sequence into individual 15mer peptides, Every overlapping by 11 amino acids.
These conclusions position EBNA-3a like a essential modulator of B cellular proliferation and survival for the duration of EBV latency, and to be a relevant CD8⁺ T mobile target in The 2 uncomplicated immunological experiments and translational examine.
Therapeutic vaccine candidates using viral vectors encoding LMP2 have effectively induced virus-precise CD8⁺ T cell responses in early-period clinical trials. Additionally, adoptive T mobile therapies like posoleucel also goal LMP2 together with other latency proteins such as EBNA1, reinforcing its importance for a conserved and immunodominant antigen.
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